Screening Pap Smears

Effective 1/1/2017, HMSA’s commercial plans include laboratory benefits for one routine screening Pap smear every 3 years for women beginning at age 21 years old through age 65 years old. This is consistent with the recommendations provided by the United States Preventive Services Task Force, Bright Futures, the American Cancer Society and the American College of Obstetricians and Gynecologists.

Claims Filing Information

The codes referenced below may be billed for screening Pap smear. Please use the appropriate code.

CPT or HCPCS code Description
88141 Cytopathology, cervical or vaginal (any reporting system); requiring interpretation by physician
88142 Cytopathology, cervical or vaginal (any reporting system), collected in preservative fluid, automated thin layer preparation; manual screening under physician supervision
88143 Cytopathology, cervical or vaginal (any reporting system), collected in preservative fluid, automated thin layer preparation; with manual screening and rescreening under physician supervision
88147 Cytopathology smears, cervical or vaginal; screening by automated system under physician supervision
88148 Cytopathology smears, cervical or vaginal; screening by automated system with manual rescreening under physician
88150 Cytopathology, slides, cervical or vaginal; manual screening under physician supervision
88152 Cytopathology, slides, cervical or vaginal; with manual screening and computer-assisted rescreening under physician supervision
88153 Cytopathology, slides, cervical or vaginal; with manual screening and rescreening under physician supervision
88154 Cytopathology, slides, cervical or vaginal; with manual screening and computer-assisted rescreening using cell selection and review under physician supervision
88155 Cytopathology, slides, cervical or vaginal, definitive hormonal evaluation (eg, maturation index, karyopyknotic index, estrogenic index) (List separately in addition to code[s] for other technical and interpretation services)
88164 Cytopathology, slides, cervical or vaginal, (the Bethesda System); manual screening under physician supervision
88165 Cytopathology, slides, cervical or vaginal (the Bethesda System); with manual screening and rescreening under physician supervision
88166 Cytopathology, slides, cervical or vaginal (the Bethesda System); with manual screening and computer-assisted rescreening under physician supervision
88167 Cytopathology, slides, cervical or vaginal (the Bethesda System); with manual screening and computer-assisted rescreening using cell selection and review under physician supervision
88174 Cytopathology, cervical of vaginal (any reporting system), collected in preservative fluid, automated thin layer preparation; screening by automated system under physician supervision
88175 Cytopathology, cervical or vaginal (any reporting system), collected in preservative fluid, automated thin layer preparation; with screening by automated system and manual rescreening or review, under physician supervision
G0123 Screening cytopathology, cervical or vaginal (any reporting system), collected in preservative fluid, automated thin layer preparation, screening by cytotechnologist under physician supervision
G0124 Screening cytopathology, cervical or vaginal (any reporting system), collected in preservative fluid, automated thin layer preparation, requiring interpretation by physician
G0141 Screening cytopathology smears, cervical or vaginal, performed by automated system, with manual rescreening, requiring interpretation by physician
G0143 Screening cytopathology, cervical or vaginal (any reporting system), collected in preservative fluid, automated thin layer preparation, with manual screening and rescreening by cytotechnologist under physician supervision
G0144 Screening cytopathology, cervical or vaginal (any reporting system), collected in preservative fluid, automated thin layer preparation, with screening by automated system, under physician supervision
G0145 Screening cytopathology, cervical or vaginal (any reporting system), collected in preservative fluid, automated thin layer preparation, with screening by automated system and manual rescreening under physician supervision
G0147 Screening cytopathology smears, cervical or vaginal, performed by automated system under physician supervision
G0148 Screening cytopathology smears, cervical or vaginal, performed by automated system with manual rescreening
P3000 Screening Papanicolaou smear, cervical or vaginal, up to 3 smears, by technician under physician supervision
P3001 Screening Papanicolaou smear, cervical or vaginal, up to 3 smears, requiring interpretation by physician

Routine readings performed by a pathologist to meet quality assurance standards should not be billed to HMSA. CPT code 88141 should be billed only when physician interpretation is needed to make a clinical diagnosis.

For professional claims, the applicable ICD-10 code must be identified as the primary line diagnosis to ensure appropriate application of benefits.

ICD-10 code Description
Z01.411 Encounter for gynecological examination (general) (routine) with abnormal findings
Z01.419 Encounter for gynecological examination (general) (routine) without abnormal findings
Z01.42 Encounter for cervical smear to confirm findings of recent normal smear following initial abnormal smear
Z12.4 Encounter for screening for malignant neoplasm of cervix

Note: The codes referenced above should not be used to represent specimen collection.

HMSA reserves the right to perform retrospective reviews.


Revision History

Date Nature of Revision
08/03/2026

Migrated to new platform.